Dr Rebecca Campbell

Dr Colin Brown
University Position

Lecturer

Department

Department of Physiology
Tel 64 3 479 7343
Fax 64 3 479 7323
Email

Interests

I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility. I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.

Current and Proposed Projects:

  • Exploring the neuroendocrine mechanisms of PCOS
  • Mechanisms of pulse generation in the GnRH neuronal network
  • Steroid induced structural plasticity within the GnRH neuronal network
Clinical conditions

infertility, PCOS, ciliopathies

Technical expertise

Light, confocal and electron microscopy, immunohistochemical techniques, stereotaxic surgery, tract tracing, cell culture

Biography

Full List of publications by year

Laboratory Staff
Research Fellow

Dr Eulalia Coutinho

Dr Elodie Desroziers

Assistant Research Fellow

Mel Prescott

PhD Student

Mauro da Silva

Chris Marshall

Selected Recent Publications

 

Moore AM, Prescott M, Marshall CJ, Yip SH, Campbell RE (2015) Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. Proc Natl Acad Sci 2015 10.1073/pnas.1415038112. OSMS Paper of the Year 2015. View abstract

Campbell RE & Herbison AE(2014) Gonadal steroid neuromodulation of developing and mature hypothalamic neuronal networks. Current Opinion in Neurobiology 29:96-102. View abstract

Moore AM, Prescott M, Campbell RE(2013) Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology 154:796-806. View abstract

Chan H, Prescott M, Ong Z, Herde MK, Herbison AE, Campbell RE (2011) Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology 152: 4906-4914. View abstract

Campbell RE, Gaidamaka G, Han SK, Herbison AE. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. Proc Natl Acad Sci U S A , 106: 10835 - 10840.View abstract

Centre for Neuroendocrinology Centre for Neuroendocrinology University of Otago